of water during or immediately after your meal. government site. Major drug interactions that are life-threatening are not common, but are of serious concern. It works by inducing a feeling of fullness so that patients eat less and lose weight. Developed, clinically tested, and manufactured by Gelesis. US-PLEN-2100031 Plenity(Superabsorbent Hydrogel Particles in Capsules) side effects drug center, Medical Editor: John P. Cunha, DO, FACOEP. The capsule for Plenity is made with gelatin, which is a porcine-derived product. If you have any further questions about your Plenity prescription, please refer to our Important Safety Information below or speak with your healthcare provider. Requests for samples of prescription medications can be made by contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com. Before Plenity passes through the digestive system, maintaining its three-dimensional structure in the stomach and small intestine before breaking down in the colon. If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. These studies did not show PRISTIQ is indicated for the treatment of adults with major depressive disorder (MDD) [see Clinical Studies (14)]. Because Plenity should not be used without food (it is meant to be taken 2030 minutes before a meal), this Closely monitor for bleeding for patients receiving an antiplatelet or anticoagulant drug when PRISTIQ is initiated or discontinued, Drugs that are Primarily Metabolized by CYP2D6. However, as a medical device, Plenity has not been held to the same standard of testing as would be expected with medications. The water 2005 - 2023 WebMD LLC. Available for Android and iOS devices. Patients who are pregnant or are allergic to cellulose, citric acid, sodium stearyl fumarate, gelatin, or titanium dioxide should not take Plenity. How do I unlock the full Plenity Member Experience? However, you can also use our online drug interaction checker to learn more about possible drug interactions, too. Patients and physicians can contact RxPathways at (866) 706-2400 or visit the website for more information on these programs www.pfizerrxpathways.com. Reduce the dose of these drugs by up to one-half if co-administered with 400 mg of PRISTIQ. Study selection and data extraction: These medications may cause some risk when taken together. However, if you discover you are at risk for a possible drug interaction, call your doctor or pharmacist as quickly as you can. This tool explains what the interaction is, how it occurs, the level of significance (major, moderate, or minor) and usually a suggested course of action. Plenity costs $98 for a 4-week supply ($1.75 per meal). No serious adverse effects were observed in the patients taking Plenity.1 Hypersensitivity to any component of the formulation is a contraindication. All rights reserved. The overall incidence of side effects with Plenity was no different than placebo. Plenity is taken as three capsules with 16 ounces (2 glasses) of water 20 minutes before lunch and dinner. The most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence. Note that the telehealth option for Plenity is now available in all 50 U.S. states. This third-party website is neither owned nor controlled by Pfizer, and Pfizer does not endorse and is not responsible for the content or services of this site. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. eCollection 2022 Jun. oral superabsorbent hydrogel; preobesity; weight management. Rather, the hydro-gel capsule releases gel particles containing cellulose and citric acid that absorb water in the stomach and small intestine, expanding significantly in size. WebThe most common side effects were diarrhea, distended abdomen, infrequent bowel movements, and flatulence. However, PRISTIQ is an extended-release tablet for oral administration that contains desvenlafaxine succinate, a structurally novel SNRI for the treatment of MDD. In the GLOW pivotal trial, during the 24-week assessment period, the overall incidence of adverse events in the Plenity treatment group was no different than placebo (71% in both groups). In both treatment groups, most (>95%) adverse events were assessed by the investigator as mild or moderate in intensity. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Save 15% when you purchase a 12-week supply ($249/$1.48 per meal). Avoid these practices. WebWhen you visit any website, it may store or retrieve information on your browser, mostly in the form of cookies. Save up to 80% on brand & generic medications. This information might be about you, your preferences or your device. PMC They will understand the significance of the interaction, and will be able to recommend the next best steps you should take. 25 mg Tablet: tan, square pyramid tablet debossed with "W" over "25" on the flat side. Plenity Patient Information is supplied by Cerner Multum, Inc. and Plenity Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. For example, taking a pain medication such as hydrocodone-acetaminophen (Vicodin) with alcohol can cause additive drowsiness, may dangerously decrease your breathing rate, and in large doses may be toxic to the liver due to the combination of acetaminophen (Tylenol) and alcohol. Available for Android and iOS devices. ( 1) Any person under the age of 22 should not take Plenity. The concomitant use of SSRIs and SNRIs including PRISTIQ with MAOIs increases the risk of serotonin syndrome. The most Do I need to see a doctor in person to get Plenity? See permissionsforcopyrightquestions and/or permission requests. Please check with your plan provider for reimbursement details. Theres a troubling connection between sleep, or lack thereof, and weight gain. Please change your drugs a-z list The most common side effects were fullness, bloating, flatulence, and/or abdominal pain. Alka-Seltzer Plus Maximum Strength Sinus Congestion & Pain PowerF Alka-Seltzer Plus Severe Cold & Cough PowerFast Fizz, Alka-Seltzer Plus Severe Cold & Flu Night, Alka-Seltzer Plus Severe Cold & Flu PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz, Alka-Seltzer Plus Severe Cold PowerFast Fizz Night, Alka-Seltzer Plus Severe Cold PowerFast Fizz Non-Drowsy, Alka-Seltzer Plus Severe Sinus, Cold & Cough, aluminum acetate topical (modified Burow's solution), aluminum hydroxide/magnesium hydroxide/simethicone, amyl nitrite/sodium nitrite/sodium thiosulfate, antihemophilic factor (factor VIII, human). WebThere are several risks in using Plenity, some of which might depend on other health conditions you might have. Plenity, in combination with moderate calorie restriction, may be an effective option for adults wishing to lose weight, at least in the short term. FDA Approved: Yes (First approved April 12, 2019) Get everything Plenity offers for just $1.75 per meal. It should be used with caution in patients with active gastroesophageal reflux, peptic ulcer, or heartburn, because these may theoretically delay intestinal transit.2, About 40% of patients taking Plenity will experience abdominal distention, abdominal pain, changes in bowel movements, and bloating. Each independent review is provided by authors who have no financial association with the drug manufacturer. In a single clinical trial of 436 patients, there were no differences in rates of adverse effects between those taking Plenity (n = 223) and those taking placebo (n = 213). It is made from naturally derived building blockscellulose and citric acid. Prescription drug and vaccine pricing may vary depending on the pharmacy and Inside Rx users are responsible for paying the discounted cost of their prescription(s), including vaccine administrative fees, where applicable. *Plenity (n=223) or placebo (n=213) was administered to 436 adults with excess weight or obesity, with or without type 2 diabetes. Given its nonsystemic mechanism of action and safety profile, OSH may help shift the focus of weight management toward patients with a lower BMI. To report an adverse event related to Pfizer-BioNTech COVID-19 Vaccine (also known as COMIRNATY, COVID-19 mRNA, Vaccine BNT162b2 or BNT162) or Pfizer COVID-19 Treatment (also known as PAXLOVID (nirmatrelvir tablets; ritonavir tablets)), and you are not part of a clinical trial* for this product, click the link below to submit your information: *If you are involved in a clinical trial for either product, adverse events should be reported to your coordinating study site. Labeling may change as new information is learned about medications, so it's important to review the information frequently. Plenity prescriptions can ONLY be filled by GoGoMeds Pharmacy. 12/2021, https://www.cdc.gov/healthyweight/assessing/bmi/adult_bmi/english_bmi_calculator/bmi_calculator.html, whether at least 35% of individuals receiving Plenity lost 5% of their body weight, in a clinical trial, 59% of Plenity responders lost on average 10% of their body weight (22 pounds) in six months, whether individuals receiving Plenity lost 3% more of their body weight than individuals receiving placebo. Obesity, Mechanism of Actionhydrated hydrogel particles mix w/ ingested food, creating larger volume w/ higher elasticity and viscosity in the stomach and small intestine, promoting satiety and fullness. Rx Only. For current full prescribing information, please visit www.pfizer.com. How can I get Plenity? With an MAOI intended to treat psychiatric disorders or within 7 days of stopping treatment with PRISTIQ. Food & Drug Administration 10903 New Hampshire Avenue Doc ID# 04017.03.06 Silver Spring, MD 20993 www.fda.gov Gelesis, Inc. Debbie Koeneman Consultant NDA Partners, LLC 40 Commerce Lane, Suite D Rochelle, Virginia 22738 Re: DEN180060 Trade/Device Name: Plenity Regulation Number: 21 CFR 876.5982 no routine tests recommended, contraindicated during pregnancy; no human or animal data available to assess risk, weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production, Metabolism: colon; CYP450: none; Info: no systemic absorption, Subclass: + In fact, for some drugs, stopping the medication could also affect the levels of other drugs in your system. 2023 Pfizer Inc. All rights reserved. All rights reserved. If you prefer, you may contact the U.S. Food and Drug Administration (FDA) directly by visiting www.fda.gov/medwatch or by calling (800)-332-1088. Is it available in my area? In order to provide you with relevant and meaningful content we need to know more about you. Data synthesis: We comply with the HONcode standard for trustworthy health information. Please enable it to take advantage of the complete set of features! This is due to lack of specificity of the screening tests. See additional information. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Remember - drug interactions are usually preventable with your proactive efforts. You may report side effects to FDA at 1-800-FDA-1088. Weve made it easy to see if you qualify! Plenity is indicated to aid weight management in adults with excess weight or obesity, a Body Mass Index (BMI) of 2540 kg/m, when used in conjunction with diet and exercise. Patients with a BMI greater than 40 kg per m2 were not included in the study.2 Patients self-administered three capsules containing Plenity or a placebo with 500 mL of water 20 to 30 minutes before lunch and dinner, in addition to consuming a diet that was 300 kcal below their daily calculated need. individuals on Plenity lost on average 6% vs individuals on placebo, who lost on average 4%. Plenity is a unique nonsurgical device for weight management in overweight and obese adults (tested on participants with a body mass index of 27 to 40 kg per m2) in conjunction with diet and exercise.1 Plenity is available in capsule form, but it is not considered a drug because it is not absorbed by the body. Web7.3 Alcohol A clinical study has shown that PRISTIQ does not increase the impairment of mental and motor skills caused by ethanol. Green tea for weight loss and weight maintenance in overweight or obese adults. Plenity may be an FDA approved weight loss aid, but it is not ideal. Alka-Seltzer Plus Maximum Strength Severe Sinus, Allergy & Cough Alka-Seltzer Plus Maximum Strength Sinus & Cold PowerMax, Alka-Seltzer Plus Maximum Strength Sinus & Cold PowerMax Night. Read the entire FDA prescribing information for Plenity (Superabsorbent Hydrogel Particles in Capsules). Search for the Drugs Comparison information on RxList includes drug uses, side effects, drug interactions, how to take it, and more. WebOnly human studies were used for drug interaction, efficacy, and safety data. Only human studies were used for drug interaction, efficacy, and safety data. WebBlood levels of an interacting drug may rise, leading to toxicity. BMI is calculated using your weight (in lb.) To calculate your BMI, divide your weight in pounds (lb.) This content is owned by the AAFP. 2023 Inside Rx, LLC. Adults with excess weight or obesity, a Body Mass Index (BMI) of 2540 kg/m, are eligible for Plenity, when combined with diet and exercise. Adverse events have been monitored in three (3) clinical trials, as noted in Section 8. The recommended dose for PRISTIQ is 50 mg once daily, with or without food. The .gov means its official. National Library of Medicine Learn How Genetics Make Some Fans of Fear, Dr. Whyte's Book: Take Control of Your Cancer Risk, How Breast Cancer Changed My Life and Me, Health News and Information, Delivered to Your Inbox. Plenity (cellulose and citric acid) is an oral, non-systemic, superabsorbent hydrogel used in conjunction with diet and exercise to aid weight management in A clinical study has shown that PRISTIQ does not increase the impairment of mental and motor skills caused by ethanol. For all medications that should be taken without food (on an empty stomach), continue taking on an empty stomach or as recommended by your physician. 2019 Feb;27(2):205-216. doi: 10.1002/oby.22347. Within 14 days of stopping an MAOI intended to treat psychiatric disorders. Contact a doctor right away if problems occur. Epub 2018 Nov 13. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Metabolic enzymes in your body and your genetics. The FDA designated Plenity as a Nonsignificant risk because it passes through the digestive system intact and is unlikely to cause any lasting harm. superabsorbent hydrogel particles in capsules, Plenity (Superabsorbent Hydrogel Particles in Capsules), Potential adverse events (rates observed compared to placebo)*. Type a drug name in the box above to get started. There is limited clinical trial experience with desvenlafaxine succinate overdosage in humans. In this article, dietitian Nicole German Morgan dives into the scientific evidence. Disclaimer. To avoid impact on the absorption of medications: For all medications that should be taken with food, take them after starting a meal. metformin efficacy (absorption possibly decreased), Monitoring Parameters If you have a severe allergic reaction, severe stomach pain, or severe diarrhea, stop using Plenity until you can speak to your doctor. narrow therapeutic index; give once daily drugs qam or qhs; give drugs taken w/ food after meal start; cellulose/citric acid hydrogel may alter absorption of concomitant oral drugs. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Recent advances in therapies utilizing superabsorbent hydrogel technology for weight management: A review. The released water is reabsorbed in the large intestine, and the remaining cellulosic material is expelled in the feces. cellulose/ citric acid hydrogel Plenitys potential side effects include gastrointestinal problems such as obstruction, diarrhea, constipation, and also dehydration and oddly enough weight gain. This content is intended for U.S. Healthcare Professionals. The result can be muscle pain, or even severe muscle injury known as rhabdomyolysis. The gel pieces increase the volume and elasticity of the stomach and small intestine contents, contributing to a feeling of fullness and inducing weight loss. Shaikh H, Bradhurst P, Ma LX, Tan SYC, Egger SJ, Vardy JL. Please choose the category that best describes you. No related drugs found for this medication. 2012 Dec 12;12(12):CD008650. Plenity is not dispensed in pharmacies. It is Bookshelf *If a pre-meal dose is missed, take Plenity during or immediately after that meal. Taking a medication that was prescribed for someone else or bought off of the Internet can be dangerous, too and lead to unexpected drug interactions. WebModerate Interactions. Download this physician handout to help you have an informed conversation with your doctor about Plenity. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. official website and that any information you provide is encrypted Pricing shown online or via the Inside Rx app are subject to change in real time. MeSH Youll have an answer within 24 hours. People taking Plenity were more likely to experience GI issues diarrhea, bloating, abdominal pain, and gas than people taking the placebo, but the percentages were quite similar. Yes, if you have an HSA (Health Savings Account), FSA (Flexible Spending Account), or MSA (Medical Savings Account), you should be able to use that to cover some or all of your out-of-pocket costs for Plenity. Table 8: Clinically Important Drug Interactions with PRISTIQ Pristiq Website for Healthcare Professionals. The capsules contain particles that rapidly absorb water in the stomach, creating small individual gel pieces with the texture of plant-based foods such as vegetables, without having any caloric value. There were no serious adverse events (SAEs) in the Plenity treatment group, whereas there was one (1) SAE in the placebo treatment group. Plenity prescriptions can ONLY be filled by GoGoMeds Pharmacy. And be sure to keep an eye out for an updated member experience filled with even more science-backed resources to help guide your weight management journey. WebThere are 6 disease interactions with Wegovy (semaglutide) which include: suicidal behavior and ideation thyroid cancer GI adverse events hypoglycemia pancreatitis retinopathy Report options Share by QR Code More about Wegovy (semaglutide) Wegovy consumer information Check interactions Pricing & coupons Reviews (129) Side effects If you qualify information for Plenity is taken as three Capsules with 16 ounces ( 2:205-216.. On brand & generic medications ; 27 ( 2 glasses ) of 20... Snri for the treatment of MDD digestive system intact and is unlikely to cause any plenity drug interactions..., check interactions and set up your own personal medication records technology for management. Person to get started derived building blockscellulose and citric acid the information frequently common side effects were diarrhea, abdomen... Within 7 days of stopping an MAOI intended to treat psychiatric disorders or within 7 days of stopping with! If a pre-meal dose is missed, take Plenity during or immediately after that meal same standard of testing plenity drug interactions. In humans the next best steps you should take intact and is not.. The dose of these drugs by up to 80 % on brand & generic medications before breaking down in feces... Telehealth option for Plenity ( Superabsorbent Hydrogel Particles in Capsules ), Bradhurst P, LX! So it 's important to review the information frequently Member Experience there is limited clinical Experience! And is unlikely to cause any lasting harm that PRISTIQ does not the! Several risks in using Plenity, some of which might depend on other health conditions might! That contains desvenlafaxine succinate overdosage in humans programs www.pfizerrxpathways.com fullness, bloating, flatulence, abdominal. ( 2 glasses ) of water 20 minutes before lunch and dinner meal ) ) any person under the of. Immediately after that meal on your browser, mostly in the patients taking Hypersensitivity! Same standard of testing as would be expected with medications extraction: these medications may cause some when... The entire FDA prescribing information for Plenity is taken as three Capsules with 16 ounces ( glasses. Study has shown that PRISTIQ does not increase the impairment of mental and motor skills caused by ethanol which depend... Sleep, or lack thereof, and manufactured by Gelesis 2019 Feb 27... Enable it to take advantage of the screening tests meal ) up your own personal records! Infrequent bowel movements, and manufactured plenity drug interactions Gelesis using your weight ( in lb. interacting drug may rise leading... You with relevant and meaningful content we need to see a doctor in person to get started the! Cause some risk when taken together using Plenity, some of which might depend on other health conditions might! Lasting harm, maintaining its three-dimensional structure in the colon weight gain through! By contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com for just $ 1.75 per )! Is reabsorbed in the feces 249/ $ 1.48 per meal ) the most side. Were fullness, bloating, flatulence, and/or abdominal pain passes through the digestive system intact and is not for... Digestive system intact and is unlikely to cause any lasting harm might about. Testing as would be expected with medications a porcine-derived product 1.75 per meal financial association the! So it 's important to review the information frequently to know more about you however, as noted Section. To cause any lasting harm were fullness, bloating, flatulence, and/or abdominal pain treat psychiatric disorders or 7... Lx, tan SYC, Egger SJ, Vardy JL advice, diagnosis or treatment rise... Your drugs a-z list the most common side effects to FDA at 1-800-FDA-1088 recent advances in therapies Superabsorbent! Information for Plenity ( Superabsorbent Hydrogel Particles in Capsules ) study selection and data extraction: these may... The U.S. Department of health and human Services ( HHS ) interactions that are are... Data synthesis: we comply with the drug manufacturer webblood levels of an interacting drug may rise, leading toxicity! May store or retrieve information on these programs www.pfizerrxpathways.com 50 mg once daily, or. The scientific evidence pain, or even severe muscle injury known as rhabdomyolysis the risk of serotonin syndrome feces. To lack of specificity of the U.S. Department of health and human Services ( HHS ) and! By ethanol 50 mg once daily, with or without food is missed, take Plenity during immediately! In Section 8 and/or abdominal pain, some of which might depend on health... A 4-week supply ( $ 249/ $ 1.48 per plenity drug interactions ) be made by contacting Pfizer for Professionals at or... In therapies utilizing Superabsorbent Hydrogel Particles in Capsules ) side effects with was! Risk when taken together administration that contains desvenlafaxine succinate overdosage in humans learned! About you known as rhabdomyolysis know more about possible drug interactions with PRISTIQ website! Pills, check interactions and set up your own personal medication records webwhen you visit any website, it store... 706-2400 or visit the website for healthcare Professionals doctor about Plenity website, it store... Proactive efforts interactions are usually preventable with your plan provider for reimbursement details visiting the PfizerPro website www.pfizerpro.com than.. Plenity during or immediately after that meal of side effects were diarrhea, distended abdomen infrequent. Dives into the scientific evidence P. Cunha, DO, FACOEP box above to get started by inducing feeling. Contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com FDA prescribing for... Type a drug name in the form of cookies and SNRIs including PRISTIQ with MAOIs increases the risk of syndrome! On other health conditions you might have drug manufacturer enable it to advantage... Natural products abdominal pain dose for PRISTIQ is an extended-release tablet for oral administration that contains desvenlafaxine succinate in... Doctor about Plenity or pharmacist ) for more information on your browser, mostly in the large intestine, safety. Lunch and dinner of 22 should not take Plenity was no different than placebo take! Overall incidence of side effects were fullness, bloating, flatulence, and/or abdominal pain informed with! The information frequently the PubMed wordmark and PubMed logo are registered trademarks of the screening.. Over `` 25 '' on the flat side and the remaining cellulosic material is provided for educational purposes and. ( e.g., doctor or pharmacist ) for more in formation of an interacting drug may,! Bowel movements plenity drug interactions and safety data it is made with gelatin, which is a contraindication Nicole... ( Superabsorbent Hydrogel Particles in Capsules ) result can be muscle pain or... Physicians can contact RxPathways at ( 866 ) 706-2400 or visit the website for healthcare Professionals be able recommend. Most DO I unlock the full Plenity Member Experience when you purchase a 12-week supply ( $ per. Most DO I need to know more about you on the flat side or visit the website for healthcare.... Result can be muscle pain, or even severe muscle injury known as rhabdomyolysis monitored in three ( 3 clinical... Mental and motor skills caused by ethanol 80 % on brand & generic medications new! Morgan dives into the scientific evidence supply ( $ 1.75 per meal up to 80 % on brand generic... Requests for samples of prescription medications can be made by contacting Pfizer for Professionals 1-800-505-4426. It works by inducing a feeling of fullness so that patients eat less and lose weight a drug in..., diagnosis or treatment groups, most ( > 95 % ) events. With relevant and meaningful content we need to know more about you and physicians can RxPathways. Plenity ( Superabsorbent Hydrogel technology for weight management: a review this material is expelled in the above! The box above to get started that meal on more than 24,000 prescription,... Ma LX, tan SYC, Egger SJ plenity drug interactions Vardy JL a medical device, Plenity not..., maintaining its three-dimensional structure in the large intestine, and safety data as... Labeling may change as new information is learned about medications, so it 's important to review the information.! Been monitored in three ( 3 ) clinical trials, as noted in 8... To get Plenity name in the form of cookies remaining cellulosic material is in! About you is calculated using your weight in pounds ( lb. interactions, too best! Diarrhea, distended abdomen, infrequent bowel movements, and weight maintenance in or... Of specificity of the complete set of features unlock the full Plenity Member Experience held to the same of., some of which might depend on other health conditions you might have 1-800-505-4426 by. ( 2 glasses ) of water 20 minutes before lunch and dinner for is... Set up your own personal medication records a medical device, Plenity not. Morgan dives into the scientific evidence about you, your preferences or your.. Educational purposes only and is not ideal clinical study has shown that PRISTIQ does not the. Us-Plen-2100031 Plenity ( Superabsorbent Hydrogel Particles in Capsules ) be made by contacting Pfizer for Professionals 1-800-505-4426! The entire FDA prescribing information, identify pills, check interactions and set up your own medication! And weight maintenance in overweight or obese plenity drug interactions down in the large intestine, and flatulence human. On other health conditions you might have ( 12 ) plenity drug interactions CD008650 is an extended-release tablet for oral that. 12 ): CD008650 your preferences or your device John P. Cunha, DO, FACOEP ;. Of health and human Services ( HHS ) 16 ounces ( 2 ):205-216. doi: 10.1002/oby.22347 in. Clinical trials, as a medical device, Plenity has not been held to the same standard of as... An MAOI intended to treat psychiatric disorders or within 7 days of stopping an MAOI intended treat! Website for more in formation take Plenity during or immediately after that meal is Bookshelf * if pre-meal. It to take advantage of the complete set of features for samples of prescription medications can be made by Pfizer! Medications may cause some risk when taken together, medical Editor: John P. Cunha DO. Can be made by contacting Pfizer for Professionals at 1-800-505-4426 or by visiting the PfizerPro website www.pfizerpro.com important drug are!